The field of organ transplantation, which involves replacing a missing or damaged organ with one from another person, is one example of when these principles have been combined. There are many more people waiting for an organ transplant then there are healthy, viable organs from donors. Thus, the medical community has had to come up with guidelines for how to decide which patients get organs first. In general, these decisions are made to optimize the survival of the organ recipient, and thus the organ itself. The organ allocation system combines three of the above principles–sickest first, first-come, first served, and prognosis–to rank patients waiting for an organ transplant. Ideally, the patient’s perceived social status or life accomplishments are not taken into account. However, factors such as lack of medical insurance, absence of social support networks, and substance abuse can be disqualifying. While this allocation system has advantages, it is inherently flawed as it is vulnerable to bias and manipulation and discriminates against low-income, disabled and persons of color.